5-aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3)

Bioorg Med Chem Lett. 2003 May 5;13(9):1577-80. doi: 10.1016/s0960-894x(03)00134-3.

Abstract

A novel series of pyrazolo[3,4-b]pyridines has been identified that are potent inhibitors of glycogen synthase kinase-3 (GSK-3).

Publication types

  • Comparative Study

MeSH terms

  • Glycogen Synthase Kinase 3 / antagonists & inhibitors*
  • Glycogen Synthase Kinase 3 / chemistry
  • Pyrazoles / chemical synthesis*
  • Pyrazoles / chemistry
  • Pyridines / chemical synthesis*
  • Pyridines / chemistry
  • Structure-Activity Relationship

Substances

  • Pyrazoles
  • Pyridines
  • Glycogen Synthase Kinase 3